James B. Weaver - He ran as the Populist candidate for US President in the 1892 elections, receiving over a million votes and 22 electoral votes.

Eugene V. Debs - Running for US President as the Social Democratic Party candidate in the 1900 election, and the Socialist Party candidate in the 1904, 1908, 1912, and 1920 elections.
Theodore Roosevelt - Ran as Bull Moose Candidate in 1912 and won 88 electoral votes.

Robert M. La Follette, Sr. - Running in the 1924 US Presidential election, “Fighting Bob” LaFollette won almost five million votes, 16.6% of the popular vote, and 13 electoral votes from his home state of Wisconsin.

John B. Anderson - Ran as an independent candidate in 1980 after dropping out of the Republican Primaries. He won 6.6% of the popular votes.

Ross Perot - Running for President in the 1992 elections, Ross Perot captured nearly 20 million votes - 18.9% of the popular vote. He ran again in 1996, winning just over 8 million votes.

Ralph Nader - His first major presidential campaign was the 2000 US election when as a Green, he won nearly 3 million votes. He is often credited with being the defining factor in the final results of the 2000 elections. He also ran as a Green in the 1996 election and as an independent in the 2004 election.